Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-5390 - Transcription profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects
Released on 23 April 2009, last updated on 27 July 2015
Down syndrome (DS) is the result of trisomy chromosome 21 but the mechanisms by which the genotype leads to the characteristic disease phenotype are unclear. We performed a microarray study using human adult brain tissue (dorsolateral prefrontal cortex) from DS subjects and healthy controls to characterise for the first time the human adult Down syndrome brain Experiment Overall Design: RNA extracted from human postmortem brain tissue from adult subjects with Down syndrome and healthy controls was hybridised to Affymetrix HG-U133A GeneChips to identify differentially expressed genes in the disease state.
transcription profiling by array, disease state
Gene expression profiling in the adult Down syndrome brain. H E Lockstone, L W Harris, J E Swatton, M T Wayland, A J Holland, S Bahn.