Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.

E-GEOD-5389 - Transcription profiling of human post-mortem brain tissue (orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls

Status
Released on 3 July 2007, last updated on 27 July 2015
Organism
Homo sapiens
Samples (21)
Array (1)
Protocols (4)
Description
Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls. Orbitofrontal cortex tissue from a cohort of 30 subjects was investigated and the final analysis included 10 bipolar and 11 control subjects. Differences between disease and control groups were identified using a rigorous statistical analysis with correction for confounding variables and multiple testing.
Experiment types
transcription profiling by array, co-expression, disease state
Contact
Citation
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-5389.idf.txt
Sample and data relationshipE-GEOD-5389.sdrf.txt
Raw data (1)E-GEOD-5389.raw.1.zip
Processed data (1)E-GEOD-5389.processed.1.zip
Array designA-AFFY-33.adf.txt
Links