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E-GEOD-53888 - ChIP-chip from lymph node-derived primary lymphocytes with anti-E2F2 and anti-SV40TAg

Status
Released on 9 January 2014, last updated on 4 May 2014
Organism
Mus musculus
Samples (12)
Array (1)
Protocols (6)
Description
E2F2 is essential for the maintenance of T lymphocyte quiescence. To identify the full set of E2F2 target genes, and to gain further understanding of the role of E2F2 in transcriptional regulation, we have performed ChIP-chip analyses across the genome of lymph node-derived T lymphocytes. Here we show that during quiescence, E2F2 binds the promoters of a large number of genes involved in DNA metabolism and cell cycle regulation, concomitant with their transcriptional silencing. We performed 3 ChIP-chip experiments with an antibody against E2F2 and another 3 ChIP-chip experiments with an antibody against SV40TAg (irrelevant antibody).
Experiment type
ChIP-chip by tiling array 
Contacts
Citation
E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes. Laresgoiti U, Apraiz A, Olea M, Mitxelena J, Osinalde N, Rodriguez JA, Fullaondo A, Zubiaga AM. , PMID:24038359
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-53888.idf.txt
Sample and data relationshipE-GEOD-53888.sdrf.txt
Raw data (2)E-GEOD-53888.raw.1.zip, E-GEOD-53888.raw.2.zip
Processed data (1)E-GEOD-53888.processed.1.zip
Additional data (1)E-GEOD-53888.additional.1.zip
Array designA-GEOD-18145.adf.txt
Links