E-GEOD-5388 - Transcription profiling of human brain tissue from subjects with bipolar disorder and healthy controls
Released on 24 June 2007, last updated on 27 July 2015
Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex) from patients with bipolar disorder and matched healthy controls. A cohort of 70 subjects was investigated and the final analysis included 30 bipolar and 31 control subjects. Differences between disease and control groups were identified using a rigorous statistical analysis with correction for confounding variables and multiple testing.
transcription profiling by array, co-expression, disease state
Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes. M M Ryan,H E Lockstone,S J Huffaker,M T Wayland,M J Webster,S Bahn. Mol Psychiatry 11(10):965-78 (2006)