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E-GEOD-53868 - Micro-array analysis of the anterior vaginal wall from premenopausal patients with Pelvic Organ Prolapse (POP)

Status
Released on 31 July 2015, last updated on 19 August 2015
Organism
Homo sapiens
Samples (24)
Array (1)
Protocols (5)
Description
Pelvic organ prolapse (POP) is a common multifactorial disease in a heterogeneous population of women. Due to this heterogeneity, the underlying molecular mechanisms contributing to the pathogenesis of POP are still unclear. We sought to identify dysregulated pathways by comparing gene expression profiles of prolapsed and non- prolapsed anterior vaginal wall tissue within the same patient. Biopsies were collected from 12 premenopausal women undergoing prolapse surgery (cystocele POP-Q stage ≥ 2). A full thickness anterior vaginal wall sample was taken from the POP site during anterior colporrhaphy. An additional sample was taken from the non-prolapsed apex of the anterior vaginal cuff. Micro-array analysis was performed using whole genome GE 4x44K microarrays. Beside a significance analysis of micro-array (SAM), also a visual cluster analysis was performed. 12 women with POP: 12 biopsies anterior vaginal wall (POP site) versus 12 biopies precervical anterior vaginal wall ( non POP site)
Experiment type
transcription profiling by array 
Contacts
Manon Heleen Kerkhof <mhkerkhof@freeler.nl>, Alejandra M Ruiz-Zapata, Behrouz Z Doulabi, Hans A Brolmann, Manon H Kerkhof, Marco N Helder, Saskia Vosslamber, Theo H Smit
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-53868.idf.txt
Sample and data relationshipE-GEOD-53868.sdrf.txt
Processed data (1)E-GEOD-53868.processed.1.zip
Additional data (1)E-GEOD-53868.additional.1.zip
Array designA-GEOD-18142.adf.txt
Links