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E-GEOD-53838 - Characterization of Gene Expression in ASS1-Deficient Breast Cancer Cells

Status
Released on 20 May 2014, last updated on 3 June 2014
Organism
Homo sapiens
Samples (3)
Array (1)
Protocols (7)
Description
Analysis of mechanism underlying the metabolic effects of ADI-PEG20 at gene expression level. The hypothesis tested in the present study was that ASS1-deficient breast cancer cells would be arginine-auxotrophs and would therefore be sensitive to arginine starvation. Results provide important information of the response of ASS1-deficient breast cancer cells to ADI-PEG20-treatment, such as the suppression of mRNAs encoding mitochondrial respiratory chain proteins. Total RNA obtained from ADI-treated, or ADI- and L-arginine-treated 231 cells compared to untreated cells.
Experiment type
transcription profiling by array 
Contacts
Cheng-Ying Chu, David K Ann, Hsing-Jien Kung
Citation
Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells. Qiu F, Chen YR, Liu X, Chu CY, Shen LJ, Xu J, Gaur S, Forman HJ, Zhang H, Zheng S, Yen Y, Huang J, Kung HJ, Ann DK. , PMID:24692592
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-53838.idf.txt
Sample and data relationshipE-GEOD-53838.sdrf.txt
Processed data (1)E-GEOD-53838.processed.1.zip
Additional data (1)E-GEOD-53838.additional.1.zip
Array designA-GEOD-10558.adf.txt
Links