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E-GEOD-53676 - A novel Lysyl oxidase like 2 alternative splicing LOXL2 △e13 in esophageal squamous carcinoma cells

Status
Released on 3 July 2016, last updated on 28 December 2016
Organism
Homo sapiens
Samples (3)
Array (1)
Protocols (5)
Description
A novel alternative splicing isoform of LOXL2 △e13 was expressed ubiquitously in all cell lines and ESCC tissues. In contrast to the impaired deamination enzymatic activity compared with full length LOXL2, LOXL2 △e13 showed an enhanced ability to promote cell mobility and invasiveness in ESCC cells than full length LOXL2 through a different mechanism. We used cDNA microarrays to identify genes that were differentially expressed upon LOXL2 △ e13 overexpressed. For this purpose, we selected LOXL2 △ e13, WT and empty vector control transfeced ESCC KYSE150 cell lines. Total RNA was extracted,compare the gene expression patterns between LOXL2 △e13, LOXL2 WT and empty vector control transfected cells through the Genechip Primeview Human Gene Expression Array.
Experiment type
transcription profiling by array 
Contact
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-53676.idf.txt
Sample and data relationshipE-GEOD-53676.sdrf.txt
Raw data (1)E-GEOD-53676.raw.1.zip
Processed data (1)E-GEOD-53676.processed.1.zip
Array designA-GEOD-15207.adf.txt
Links