Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.

E-GEOD-52636 - The effect of a novel form of macrophage colony-stimulating factor (CSF1-Fc) on gene expression in the liver

Status
Released on 31 December 2013, last updated on 3 June 2014
Organism
Mus musculus
Samples (5)
Array (1)
Protocols (7)
Description
Treatment of mice with daily injections of CSF1-Fc produce a 50% increase in the size of the liver within 5 days. There was extensive proliferation of hepatocytes, similar to that seen following partial hepatectomy. Comparative gene expression profiles of the treated and control livers, alongside macrophages grown in CSF1, indicate extensive infiltration by macrophages in response to CSF1-Fc, and demonstrate that infiltrating macrophages produced several candidate mediators of hepatocyte proliferation.
Experiment type
transcription profiling by array 
Contacts
Kristin Sauter <kristin.sauter@roslin.ed.ac.uk>, David A Hume, Deborah J Gow, Kristin A Sauter
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-52636.idf.txt
Sample and data relationshipE-GEOD-52636.sdrf.txt
Raw data (1)E-GEOD-52636.raw.1.zip
Processed data (1)E-GEOD-52636.processed.1.zip
Array designA-GEOD-11533.adf.txt
Links