Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-52636 - The effect of a novel form of macrophage colony-stimulating factor (CSF1-Fc) on gene expression in the liver
Released on 31 December 2013, last updated on 3 June 2014
Treatment of mice with daily injections of CSF1-Fc produce a 50% increase in the size of the liver within 5 days. There was extensive proliferation of hepatocytes, similar to that seen following partial hepatectomy. Comparative gene expression profiles of the treated and control livers, alongside macrophages grown in CSF1, indicate extensive infiltration by macrophages in response to CSF1-Fc, and demonstrate that infiltrating macrophages produced several candidate mediators of hepatocyte proliferation.
transcription profiling by array
Kristin Sauter <email@example.com>, David A Hume, Deborah J Gow, Kristin A Sauter