E-GEOD-52563 - Genome-wide analysis of serum starved prelamin A-accumulating hMSCs gene expression

Released on 23 June 2014, last updated on 28 June 2014
Homo sapiens
Samples (6)
Array (1)
Protocols (12)
Analysis of serum starved prelamin A-accumulating hMSCs at gene expression level. The hypothesis tested in the present study was that prelamin A accumulation induces the dysregulation of genes that are essensial for cell survival under a stress condition such as serum starvation. The results provide important information about these genes and the functional categories that are dysregulated due to prelamin A accumulation in serum starved hMSCs. Two samples are analyzed in this microarray experiment: human mesenchymal stem cell cultured under serum starvation conditions (during 24 hours) which accumulate prelamin A (pre-hMSCs) and control mesenchymal stem cells (ctrl-hMSCs). 2 biological replicates (hMSCs derived from 2 different bone marrow donors) and 1 technical replicate are included in this analysis.
Experiment type
transcription profiling by array 
Clara Isabel Rodriguez <geo@ncbi.nlm.nih.gov>, Andrea Gago, Arantza Infante, Clara I Rodríguez, Garbiñe Ruiz de Eguino
Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal stem cell. Infante A, Gago A, de Eguino GR, Calvo-Fern�ndez T, G�mez-Vallejo V, Llop J, Schlangen K, Fullaondo A, Aransay AM, Mart�n A, Rodr�guez CI.
Investigation descriptionE-GEOD-52563.idf.txt
Sample and data relationshipE-GEOD-52563.sdrf.txt
Processed data (1)E-GEOD-52563.processed.1.zip
Additional data (1)E-GEOD-52563.additional.1.zip
Array designA-GEOD-10558.adf.txt