E-GEOD-5255 - Transcription profiling of whole lungs from mice expressing an inducible dominant negative BMPR2 transgene to study the effect of BMPR2 on gene expression

Status
Submitted on 6 July 2006, released on 27 November 2007, last updated on 27 March 2012
Organism
Mus musculus
Samples (6)
Array (1)
Protocols (3)
Description
Mice expressing a doxycycline-inducible dominant negative BMPR2 transgene expressed only in smooth muscle are activated for one or eight weeks, and compared to transactivator-only mice also fed doxycycline. All mice are 12 weeks of old at sacrifice. Experiment Overall Design: Each chip is a pool of three individual mice, to reduce variability. The transactivator-only mice are controls. The other mice all had elevated RV pressures at time of sacrifice. RNA was prepared from whole lung.
Experiment types
transcription profiling by array, co-expression, individual genetic characteristics, sex, time series
Contact
Citation
Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH. Tada Y, Majka S, Carr M, Harral J, Crona D, Kuriyama T, West J. Am J Physiol Lung Cell Mol Physiol 292(6):L1556-63 (2007)
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-5255.idf.txt
Sample and data relationshipE-GEOD-5255.sdrf.txt
Processed data (1)E-GEOD-5255.processed.1.zip
Array designA-AFFY-45.adf.txt
Links