Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-52539 - Global analysis of the nuclear processing of unspliced U12-type introns by the exosome
Released on 26 May 2014, last updated on 20 June 2014
we analyzed globally the effect of exosome processing on the nuclear pre-mRNA transcripts by inactivating either the RRP41 or DIS3 subunit of the exosome. Using SOLiD RNA sequencing technology, we report 30-120 million mapped cellular compartment specific reads per sample allowing the detection of unspliced pre-mRNAs. We show that RRP41 and DIS3 knockdowns stabilize an overlapping set of U12-type introns. Studying the global effect of the exosome (Rrp41 or Dis3 subunit) knockdown comparing to the control sample.
other, RNA-seq of coding RNA, RNA-seq of non coding RNA
Mikko Juhani Frilander <firstname.lastname@example.org>, Ali Oghabian, Dario Greco, Elina H Niemelä, Ger Pruijn, Mikko J Frilander, Raymond H Staals