Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.

E-GEOD-51732 - Epigenetic silencing of noncoding RNA nc886 provokes oncogenes during esophageal tumorigenesis

Status
Released on 31 October 2013, last updated on 3 June 2014
Organism
Homo sapiens
Samples (18)
Array (1)
Protocols (5)
Description
nc886 is a 101 nucleotides long non-coding RNA that is also known as a precursor microRNA or a vault RNA. nc886 has been suggested to be a tumor suppressor, mainly inferred by its expression pattern as well as its genomic location at human chromosome 5q31, a locus for a tumor suppressor gene(s). Pre-clinical study In order to understand potential roles of nc886 in esophageal squamous cell carcinoma (ESCC), we performed the knockdown of nc886 in nonmalignant HET-1A cells and ESCC cell lines (TE-1 and TE-8) and identified and analyzed genes whose expression is activated by nc886 knockdown in ESCC.
Experiment type
transcription profiling by array 
Contacts
Sangbae Kim <skim9@mdanderson.org>, Hyun-Sung Lee, Ju-Seog Lee, Yong-Sun Lee
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-51732.idf.txt
Sample and data relationshipE-GEOD-51732.sdrf.txt
Processed data (1)E-GEOD-51732.processed.1.zip
Additional data (1)E-GEOD-51732.additional.1.zip
Array designA-GEOD-10558.adf.txt
Links