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E-GEOD-5140 - Transcription profiling of brains from mice fed with or without creatine supplementation to study the molecular mechanism of creatine improving health and life span in mice
Released on 22 November 2007, last updated on 30 April 2015
Here we show that oral creatine (Cr) supplementation leads to increased life span in mice. Treated mice showed improved neurobehavioral performance, decreased accumulation of the aging pigment lipofuscin and upregulation of anti-aging genes in brain. As Cr is virtually free of adverse effects, it may be a promising food supplement for healthy aging in man. Experiment Overall Design: 6 biological replicates for creatine-treated mice, 7 biological replicates for untreated mice.
transcription profiling by array, co-expression, compound treatment
Creatine improves health and survival of mice. Beckers Bender, Hölter Schneider, Ruthsatz Haack, Becker Vogt-Weisenhorn, Rujescu Genius, Mijalski Irmler, Quintanilla-Martinez Mader, Gailus-Durner Fuchs, Wurst de Angelis, Klopstock Schmidt.