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E-GEOD-51158 - Afghan Hindu Kush: where Eurasian sub-continent gene flows converge

Status
Released on 4 November 2013, last updated on 3 June 2014
Organism
Homo sapiens
Samples (24)
Array (1)
Protocols (28)
Description
Despite being located at the crossroads of Asia, genetics of the Afghanistan populations have been largely overlooked. It is currently inhabited by five major ethnic populations: Pashtun, Tajik, Hazara, Uzbek and Turkmen. Here we present autosomal from a subset of our samples, mitochondrial and Y- chromosome data from over 500 Afghan samples among these 5 ethnic groups. This Afghan data was supplemented with the same Y-chromosome analyses of samples from Iran, Kyrgyzstan, Mongolia and updated Pakistani samples (HGDP-CEPH). The data presented here was integrated into existing knowledge of pan-Eurasian genetic diversity. The pattern of genetic variation, revealed by structure-like and Principal Component analyses and Analysis of Molecular Variance indicates that the people of Afghanistan are made up of a mosaic of components representing various geographic regions of Eurasian ancestry. The absence of a major Central Asian-specific component indicates that the Hindu Kush, like the gene pool of Central Asian populations in general, is a confluence of gene flows rather than a source of distinctly autochthonous populations that have arisen in situ: a conclusion that is reinforced by the phylogeography of both haploid loci. 24 samples were analysed with the Illumina platform Human660W-Quad v1.0 Genotyping BeadChip and are described herein.
Experiment types
genotyping by array, comparative genomic hybridization by array 
Contacts
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-51158.idf.txt
Sample and data relationshipE-GEOD-51158.sdrf.txt
Processed data (2)E-GEOD-51158.processed.1.zip, E-GEOD-51158.processed.2.zip
Additional data (1)E-GEOD-51158.additional.1.zip
Array designA-GEOD-8888.adf.txt
Links