Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-51013 - Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways
Released on 18 February 2016, last updated on 27 February 2016
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circuits in the heart. We identified novel miRNA-dependant networks involved in critical biological pathways, which are differentially utilized between the infarcted mouse heart and the regenerating zebrafish heart. 2 conditions, 4 biological replicates per condition
transcription profiling by array
Mark Ibberson <firstname.lastname@example.org>, Alexandre Sarre, Corinne Berthonneche, Daniel Schorderet, Dario Diviani, Gaëlle Boisset, Ioannis Xenarios, Keith Harshman, Mohammed Nemir, Samir Ounzain, Stefania Crippa, Thierry Pedrazzini
Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways. Crippa S, Nemir M, Ounzain S, Ibberson M, Berthonneche C, Sarre A, Boisset G, Maison D, Harshman K, Xenarios I, Diviani D, Schorderet D, Pedrazzini T. , PMID:26857418