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E-GEOD-51012 - Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways

Status
Released on 15 February 2016, last updated on 21 February 2016
Organism
Mus musculus
Samples (12)
Array (1)
Protocols (5)
Description
The mammalian heart has poor regenerative capacity following injury. In contrast, certain lower vertebrates such as zebrafish retain a robust capacity for regeneration into adult life. Here we use an integrated approach to identify evolutionary conserved regenerative miRNA-dependant regulatory circuits in the heart. We identified novel miRNA-dependant networks involved in critical biological pathways, which are differentially utilized between the infarcted mouse heart and the regenerating zebrafish heart. 2 conditions, 6 biological replicates per condition
Experiment type
transcription profiling by array 
Contacts
Mark Ibberson <geo@ncbi.nlm.nih.gov>, Alexandre Sarre, Corinne Berthonneche, Daniel Schorderet, Dario Diviani, Gaëlle Boisset, Ioannis Xenarios, Keith Harshman, Mohammed Nemir, Samir Ounzain, Stefania Crippa, Thierry Pedrazzini
Citation
Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways. Crippa S, Nemir M, Ounzain S, Ibberson M, Berthonneche C, Sarre A, Boisset G, Maison D, Harshman K, Xenarios I, Diviani D, Schorderet D, Pedrazzini T. , PMID:26857418
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-51012.idf.txt
Sample and data relationshipE-GEOD-51012.sdrf.txt
Raw data (1)E-GEOD-51012.raw.1.zip
Processed data (1)E-GEOD-51012.processed.1.zip
Array designA-GEOD-10740.adf.txt
Links