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E-GEOD-50397 - Global transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism [expression array]
Released on 17 July 2014, last updated on 18 July 2014
Here we harnessed the potential of expression arrays in 89 human pancreatic islet donors (different levels of blood glucose (HbA1c)) to identify genes regulated in this relevant tissue for type 2 diabetes (T2D). Islets from cadaver donors were provided by the Nordic Islet Transplantation Programme (www.nordicislets.org), Uppsala University. The microarrays were performed using GeneChip® Human Gene 1.0 ST whole transcript according to Affymetrix standard protocol.
transcription profiling by array
Joao Fadista <email@example.com>, João Fadista, Leif Groop
TCF7L2 is a master regulator of insulin production and processing. Zhou Y, Park SY, Su J, Bailey K, Ottosson-Laakso E, Shcherbina L, Oskolkov N, Zhang E, Thevenin T, Fadista J, Bennet H, Vikman P, Wierup N, Fex M, Rung J, Wollheim C, Nobrega M, Renstrï¿½m E, Groop L, Hansson O. , PMID:25015099