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E-GEOD-50397 - Global transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism [expression array]

Status
Released on 17 July 2014, last updated on 18 July 2014
Organism
Homo sapiens
Samples (89)
Array (1)
Protocols (6)
Description
Here we harnessed the potential of expression arrays in 89 human pancreatic islet donors (different levels of blood glucose (HbA1c)) to identify genes regulated in this relevant tissue for type 2 diabetes (T2D). Islets from cadaver donors were provided by the Nordic Islet Transplantation Programme (www.nordicislets.org), Uppsala University. The microarrays were performed using GeneChip® Human Gene 1.0 ST whole transcript according to Affymetrix standard protocol.
Experiment type
transcription profiling by array 
Contacts
Joao Fadista <joao.fadista@med.lu.se>, João Fadista, Leif Groop
Citation
TCF7L2 is a master regulator of insulin production and processing. Zhou Y, Park SY, Su J, Bailey K, Ottosson-Laakso E, Shcherbina L, Oskolkov N, Zhang E, Thevenin T, Fadista J, Bennet H, Vikman P, Wierup N, Fex M, Rung J, Wollheim C, Nobrega M, Renstr�m E, Groop L, Hansson O. , PMID:25015099
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-50397.idf.txt
Sample and data relationshipE-GEOD-50397.sdrf.txt
Raw data (2)E-GEOD-50397.raw.1.zip, E-GEOD-50397.raw.2.zip
Processed data (1)E-GEOD-50397.processed.1.zip
Array designA-AFFY-141.adf.txt
Links