E-GEOD-49406 - Expression analysis of YAP and Angiomotin target genes
Released on 21 October 2013, last updated on 3 June 2014
To assess changes in gene expression regulated by Yap1 or Angiomotin, either Yap1 or Angiomotin were knocked down in HEK293 cells using shRNA and expression was assessed by microarray analysis and compared to expression patterns of wildtype cells. Microarray analysis was performed to compare gene expression in Amot-KD, Yap-KD, and control HEK293 cells. Samples from three individual experiments for each of the three groups were analyzed.
transcription profiling by array
Akihiko Shimono, Anat Stemmer-Rachamimov, Ben Z Stanger, Chunling Yi, Joseph L Kissil, Lars Holmgren, Louise C Showe, Marco Giovannini, Marius Sudol, Noor Dawany, Qin Liu, Scott Troutman, Zhewei Shen
The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis. Yi C, Shen Z, Stemmer-Rachamimov A, Dawany N, Troutman S, Showe LC, Liu Q, Shimono A, Sudol M, Holmgren L, Stanger BZ, Kissil JL. , Europe PMC 24003254