Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-49248 - KrasG12D partially compensates for the loss of beta-catenin in MLL-AF9 AML
Released on 2 July 2014, last updated on 16 July 2014
The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in MLL-AF9 AML. We evaluated the dependance on beta-catenin for KrasG12DMLL-AF9 leukemia. Lin-Kit+ bone marrow cells obtained from mice transplanted with primary MLL-AF9 leukemia cells and KRasG12DMLL-AF9 leukemia cells were assessed for gene expression in the presence or absence of beta-catenin
transcription profiling by array
Amit Sinha <email@example.com>, Cherry E Ng, Demetrios Kalaitzidis, Scott Armstrong