Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-49237 - Analysis of TBR1 downnstream target genes in embryonic forebrains
Released on 31 December 2013, last updated on 20 July 2015
TBR1 is a forebrain specific T-box transcription factor. Tbr1-/- mice have been characterized by defective axonal projections from cerebral cortex and abnormal neuronal migration of cerebral cortex and amygdala. To investigate how TBR1 regulates neural development, the gene expression profile of Tbr1-/- brains was compared with WT littermates. Total RNAs purified from forebrains at embryonic day 16.5 were hybridized on Affymetrix microarrays
transcription profiling by array
Yi-Ping Hsueh <firstname.lastname@example.org>, Wen-His Chou
Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. Huang TN, Chuang HC, Chou WH, Chen CY, Wang HF, Chou SJ, Hsueh YP.