E-GEOD-48996 - Genome-wide maps of Nup98 binding in human embryonic stem cells, neural progenitors, neuron cells and lung fibroblasts
Released on 17 July 2013, last updated on 5 September 2013
Recent evidence suggests that nucleoporins, well known components that control nucleo-cytoplasmic trafficking, have wide-ranging functions in developmental gene regulation that potentially extend beyond their role in nuclear transport. Whether the unexpected role of nuclear pore proteins in transcription regulation, which initially has been described in fungi and flies, also applies to human cells is unknown. Here we show at a genome-wide level that the nuclear pore protein NUP98 associates with developmentally regulated genes active during human embryonic stem cell differentiation. Examination of Nup98 binding using multiple Nup98 antibodies in four cell types, three of which are related by direct lineage.
William Harvey Light <firstname.lastname@example.org>, Martin Hetzer, Yun Liang
Dynamic association of NUP98 with the human genome. Liang Y, Franks TM, Marchetto MC, Gage FH, Hetzer MW. , Europe PMC 23468646