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E-GEOD-48961 - The effect of vitamin D supplementation on tumorigenesis in a thioacetamide (TAA)-induced rat intrahepatic cholangiocarcinoma model
Released on 1 August 2015, last updated on 19 August 2015
In this study, we investigated the effect of vitamin D supplementation on tumorigenesis in a thioacetamide (TAA)-induced rat intrahepatic cholangiocarcinoma model as vitamin D is known to have a spectrum of anticancer activities. Using PET, we found that tumor formation and progression were suppressed in rats fed a diet supplemented with 6 IU/g vitamin D3(+6D) as compared to the group fed a 2 IU/g vitamin D3 diet (+2D) or controls. Microarray analysis of the tumors that arose revealed that vitamin D supplementation caused significant up- and down regulation in 21 and 16 genes, respectively. There are 9 tissue samples (3 rats in each group labeled as (+6), (+2) and control). Duplicate analysis were used for each sample.
transcription profiling by array
Chun-Nan Yeh <email@example.com>, Atsushi Kittaka, Chi-Chin Sun, Horng-Heng Juang, Jong-Hwei S Pang, Kun-Chun Chiang, Kun-Ju Lin, Li-Jen Su, Miin-Fu Chen, Ta-Sen Yeh, Tai C Chen, Tzu-Chen Yen, Yi-Yin Jan