E-GEOD-48419 - Gene expression analysis of Ash1l mutant mouse embryonic stem cells
Released on 20 November 2013, last updated on 27 November 2013
Using wild type and Ash1l deltaSET mutant embryonic stem cells, here we report differences of gene expression pattern under undifferentiated state and differentiated state. Interestingly, gene expression changes are frequently observed in a subset of gene group that is regulated by Polycomb group proteins. Examination of 2 cell types in 2 different conditions.
RNA-seq of coding RNA
Takaho A. Endo <email@example.com>, Jafar Sharif, Ken Higashimoto, Kenichi Nishioka, Takaho A Endo
Ash1l methylates lys36 of histone h3 independently of transcriptional elongation to counteract polycomb silencing. Miyazaki H, Higashimoto K, Yada Y, Endo TA, Sharif J, Komori T, Matsuda M, Koseki Y, Nakayama M, Soejima H, Handa H, Koseki H, Hirose S, Nishioka K. , Europe PMC 24244179