E-GEOD-48280 - Expression data from inflammatory myopathies

Status
Released on 1 December 2013, last updated on 9 December 2013
Organism
Homo sapiens
Samples (19)
Array (1)
Protocols (6)
Description
MHC-I overexpression in muscle biopsies is a hallmark of inflammatory myopathies.However the mechanisms of MHC-I overexpression in each disease is not well understood. Microarray analysis from MHC-I-microdissected myofibers showed a differential expression signature in each inflammatory myopathy. Innate immunity and IFN-I pathways are upregulated vs healthy controls, specifically in dermatomyositis (DM). RNA from MHC-I-positive myofibers were obtained from muscle biopsies of 5 patients with dermatomyositis, 5 with polymyositis, 4 with inclusion body myositis and normal looking fibers from healthy controls.
Experiment type
transcription profiling by array 
Contacts
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-48280.idf.txt
Sample and data relationshipE-GEOD-48280.sdrf.txt
Raw data (1)E-GEOD-48280.raw.1.zip
Processed data (1)E-GEOD-48280.processed.1.zip
Array designA-AFFY-141.adf.txt
Links