E-GEOD-47476 - microRNA profiles of EZH2 activation

Released on 28 October 2013, last updated on 3 June 2014
Homo sapiens
Samples (12)
Array (1)
Protocols (7)
Enhancer of Zeste Homolog 2 (EZH2) is a histone methyltransferase that catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3). EZH2 expression is significantly upregulated in MPNST. In our study, we investigated the function of EZH2 and the molecular mechanisms that are regulated by EZH2 in MPNST pathogenesis. Our findings enhance the knowledge of EZH2’s function and biology, and have the potential to provide a novel therapeutic approach for MPNST patients in the clinic. An EZH2 knockdown experiment was carried out in MPNST cells. There are one control and one siEZH2 samples for three cell lines (724,462,26T) and two repeats for each cell line, so in total there are 8 samples. Two group comparison Two group comparison
Experiment type
transcription profiling by array 
Chad Creighton <creighto@bcm.tmc.edu>, Lev Dina, Pingyu Zhang, Yiqun Zhang
EZH2/miR-30d/KPNB1 pathway regulates malignant peripheral nerve sheath tumor cell survival and tumorigenesis. Zhang P, Garnett J, Creighton CJ, Sannaa GA, Igram DR, Lazar A, Liu X, Liu C, Pollock RE. , Europe PMC 24132643
Investigation descriptionE-GEOD-47476.idf.txt
Sample and data relationshipE-GEOD-47476.sdrf.txt
Raw data (1)E-GEOD-47476.raw.1.zip
Processed data (1)E-GEOD-47476.processed.1.zip
Array designA-GEOD-17197.adf.txt