E-GEOD-47077 - Multi-region copy-number analysis
Released on 4 June 2013, last updated on 17 June 2013
Intra-tumour heterogeneity (ITH) foster tumour adaptation and hamper the efficiency of personalised medicine approaches. We investigated the extent of ITH within individual clear cell renal cell carcinomas (ccRCC) by multi-region sampling and copy number analysis. We analyzed 63 tumour regions and 8 normal samples from eight clear cell renal cell carcinomas using Affymetrix SNP6 arrays. All individual tumours were subjected to multi-region sampling and copy-number analysis using Affymetrix SNP6 arrays.
genotyping by array, comparative genomic hybridization by array
Andrew Rowan, Charles Swanton, Pierre Martinez
Parallel evolution of tumor subclones mimics diversity between tumors. Martinez P, Birkbak NJ, Gerlinger M, McGranahan N, Burrell R, Rowan A, Joshi T, Fisher R, Larkin J, Szallasi Z, Swanton C. , PMID:23716380