E-GEOD-46684 - Expression data: Venous malformation-causative TIE2-mutations mediate an AKT-dependent decrease in PDGFB
Released on 4 June 2013, last updated on 3 June 2014
Comparison of transcriptional profiles of human umbilical vein endothelial cells (HUVECs) expressing wild-type vs. VM-causative mutant forms of TIE2/TEK. The effects of the most common Venous Malformation-causative mutations in the endothelial cell tyrosine kinase receptor: R849W and L914F, were tested. 743 genes were differentially expressed across the four groups. The 80 genes distinguishing between L914F and wild-type TIE2-expressing HUVECs were analyzed in greater detail. 3 batches each of: non-transfected, and wild-type TIE2, R849W-TIE2, and L914F-TIE2 overexpressing HUVECs were compared by exon-array profiling.
transcription profiling by array
Melanie Uebelhoer, Miikka Vikkula, Nisha Limaye
Venous malformation-causative TIE2 mutations mediate an AKT-dependent decrease in PDGFB. Uebelhoer M, Nï¿½tynki M, Kangas J, Mendola A, Nguyen HL, Soblet J, Godfraind C, Boon LM, Eklund L, Limaye N, Vikkula M. , Europe PMC 23633549