E-GEOD-46583 - Expression data from neuroblastoma of TH-MYCN/KI Alk mice

Status
Released on 24 June 2014, last updated on 28 June 2014
Organism
Mus musculus
Samples (31)
Array (1)
Protocols (7)
Description
Neuroblastoma is an embryonal neoplasm that remains of dramatic prognosis in its aggressive forms. Activating mutations of the ALK tyrosine kinase receptor have been identified in sporadic and familial cases of this cancer. We generated knock-in mice carrying the two most frequent Alk mutations observed in neuroblastoma patients. We used microarrays to detail the global programme of gene expression underlying the impact of ALK mutations on neuroblastoma formation in a MYCN amplified background. We selected several murine neuroblastoma tumors for RNA extraction and hybridization on Affymetrix microarrays. We generated three groups of tumors: 10 MYCN amplified tumors, 11 MYCN amplified/ALK F1174L tumors and 10 MYCN amplified/ALK R1275Q tumors.
Experiment type
transcription profiling by array 
Contacts
Alex Cazes <alex.cazes@curie.fr>, Isabelle Janoueix-Lerosey
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-46583.idf.txt
Sample and data relationshipE-GEOD-46583.sdrf.txt
Raw data (1)E-GEOD-46583.raw.1.zip
Processed data (1)E-GEOD-46583.processed.1.zip
Array designA-GEOD-16225.adf.txt
Links