E-GEOD-46496 - Atrial Identity Is Determined by A COUP-TFII Regulatory Network (RNA)
Released on 7 June 2013, last updated on 3 June 2014
Atria and ventricles exhibit distinct molecular profiles that produce structural and functional differences between the two cardiac compartments. However, factors that determine these differences remain largely undefined. Cardiomyocyte-specific COUP- TFII ablation produces ventricularized atria that exhibit ventricle-like action potentials, increased cardiomyocyte size, and development of extensive T-tubules. We used microarrays to examine the molecular profile of cardiomyocyte-specific COUP-TFII knockout adult atria in comparison with that of normal atria. We extracted RNA from mutant right atria, control right atria and control ventricles from 2 months old adult mice, followed by gene expression profiling using Affymetrix microarrays.
transcription profiling by array
San-pin Wu <email@example.com>, Ming-Jer Tsai, Sophia Y Tsai
Atrial Identity Is Determined by a COUP-TFII Regulatory Network. Wu SP, Cheng CM, Lanz RB, Wang T, Respress JL, Ather S, Chen W, Tsai SJ, Wehrens XH, Tsai MJ, Tsai SY. , Europe PMC 23725765