E-GEOD-464 - Transcription profiling time series analyzing the molecular events in rat spinal cord sections following mechanical injury

Released on 4 September 2007, last updated on 2 May 2014
Rattus norvegicus
Samples (544)
Arrays (3)
Protocols (2)
Summary: Spinal cord injury (SCI) is a damage to the spinal cord induced by trauma or disease resulting in a loss of mobility or feeling. SCI is characterized by a primary mechanical injury followed by a secondary injury in which several molecular events are altered in the spinal cord often resulting in loss of neuronal function. Hypothesis: Spinal cord injury (SCI) induces a cascade of molecular events including the activation of genes associated with transcription factors, inflammation, oxidative stress, ionic imbalance, apoptosis and neuroregeneration which suggests the existance of endogenous reparative attempts. However, not all mechanisms following SCI are well known. Specific Aim: The goal of this project is to analyze the molecular events following spinal cord injury 1 cm above, below, and at the site of injury (T9), aiming at finding potential new targets to improve recovery and therapy.
Experiment types
transcription profiling by array, co-expression, injury, organism part comparison, time series
Gene profiling in spinal cord injury shows role of cell cycle in neuronal death. Simone Di Giovanni, Susan M Knoblach, Cinzia Brandoli, Sadia A Aden, Eric P Hoffman, Alan I Faden.