E-GEOD-46141 - Expression data from fine-needle aspiration biopsies of breast cancer metastases from different anatomical sites
Released on 2 December 2013, last updated on 9 December 2013
Breast cancer molecular subtypes preferentially metastasize to specific organs and the anatomical location of the metastasis is associated with the length of survival post-recurrence. We used microarrays to provide a detailed characterization of breast cancer site-specific metastases with particular focus on identifying genes predictive of breast cancer liver metastatic proprnsity We performed global gene expression profiling on fine-needle aspirates of metastatic lesions from different anatomical sites obtained from breast cancer patients treated within the Swedish randomized trial (TEX) of first-line chemotherapy for locally advanced or metastatic breast cancer. Samples were collected before commencement of treatment.
transcription profiling by array
Siker Kimbung <email@example.com>, Ingrid Hedenfalk, Thomas Hatschek
Claudin-2 is an independent negative prognostic factor in breast cancer and specifically predicts early liver recurrences. Kimbung S, Kovï¿½cs A, Bendahl PO, Malmstrï¿½m P, Fernï¿½ M, Hatschek T, Hedenfalk I. , Europe PMC 24287398