E-GEOD-45816 - miRNA profiling in HEV71-infected SH-SY5Y cells

Status
Released on 31 July 2014, last updated on 2 August 2014
Organism
Homo sapiens
Samples (4)
Array (1)
Protocols (7)
Description
MicroRNA (miRNA) has been highlighted in pathogen-host interactions, however, little is known about roles of miRNAs in neurological pathogenesis of human enterovirus 71 (HEV71) infections. In this study, the comprehensive miRNA expression profiling in HEV71-infected human neuroblastoma SH-SY5Y cells were performed to identify cellular miRNAs response to HEV71. A total of 69 miRNAs were differentially expressed in HEV71-infected SH-SY5Y cells compared to non-infected cells. These findings provide new information on the miRNA and mRNA profiles in HEV71 infection, which may serve as a basis for further investigation into the biological functions of miRNAs in the neurological pathogenesis of HEV71 infections. Human neuroblastoma SH-SY5Y cells were infected with HEV71. After infection, the cells were harvested and extracted total RNA for miRNA profiling by hybridization on Affymetrix microarrays. A total of 69 miRNAs were differentially expressed inHEV71-infected SH-SY5Y cells compared to non-infected cells.
Experiment type
transcription profiling by array 
Contacts
li juan <lijuanxu0312@163.com>, ChengFeng Qin, LiJuan Xu
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-45816.idf.txt
Sample and data relationshipE-GEOD-45816.sdrf.txt
Raw data (1)E-GEOD-45816.raw.1.zip
Processed data (1)E-GEOD-45816.processed.1.zip
Array designA-GEOD-14613.adf.txt
Links