E-GEOD-44274 - Gene Expression Analysis of Host Innate Immune Responses in the Central Nervous System following Lethal CVS-11 Infection in Mice

Released on 1 October 2013, last updated on 2 June 2014
Mus musculus
Samples (24)
Array (1)
Protocols (6)
The microarray and advanced pathway analysis of mice caused a paralysis in a fatal infection of a highly pathogenic CVS-11 was performed for the understanding of the detail gene networks and biological functions of inflammatory response and the related genes of innate immunity and apoptosis. Female BALB/c mice were used at 21 weeks of age. Mice were subcutaneously immunized with UV inactivated SARS-CoV (UV-V) or UV-V and Toll like receptor (TLR) ligands at 6 and 1 weeks prior to mouse-adapted SARS-CoV (n=6 per group). PBS was used in three mice as control immunization. Mice were intranasally challenged with 1E+6TCID50 in 30μL. Mice were sacrificed and collected lungs at 1 days after challenge. These mice were used for the analysis of microarray.
Experiment type
transcription profiling by array 
Naoko Iwata-Yoshikawa <inok@nih.go.jp>, A Uda, H Hasegawa, N Iwata-Yoshikawa, N Nagata, T Sata, Y Sato, Y Tsunetsugu-Yokota
Investigation descriptionE-GEOD-44274.idf.txt
Sample and data relationshipE-GEOD-44274.sdrf.txt
Raw data (1)E-GEOD-44274.raw.1.zip
Processed data (1)E-GEOD-44274.processed.1.zip
Array designA-GEOD-10787.adf.txt