Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-43685 - Early growth response protein-1 coordinates lipotoxicity-associated placental inflammation: Role in Maternal Obesity
Released on 21 January 2014, last updated on 2 June 2014
Maternal obesity during pregnancy leads to a pro-inflammatory milieu in the placenta. We conducted a global transcriptomic profiling in BeWo cells following palmitic acid (PA, 500 uM) and/or TNF-alpha (10 ng/ml) treatment for 24 h. Microarray analysis revealed that placental cytotrophoblasts increased expression of genes related to inflammation, stress response and immediate-early factors in response to plamitic acid, TNF-alpha or a combination of both. Our results suggest that fatty acids and inflammatory cytokines induce inflammation in placental cells via activation of JNK-Egr-1 signaling. global transcriptomic profiling in BeWo cells following palmitic acid (PA, 500 uM) and/or TNF-alpha (10 ng/ml) treatment for 24 h
transcription profiling by array
Kartik Shankar <firstname.lastname@example.org>, Aline Andres, Horacio Gomez-Acevedo, Jessica Saben, Keshari M Thakali, Sarah J Borengasser, Ying Zhong