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E-GEOD-43685 - Early growth response protein-1 coordinates lipotoxicity-associated placental inflammation: Role in Maternal Obesity

Status
Released on 21 January 2014, last updated on 2 June 2014
Organism
Homo sapiens
Samples (8)
Array (1)
Protocols (7)
Description
Maternal obesity during pregnancy leads to a pro-inflammatory milieu in the placenta. We conducted a global transcriptomic profiling in BeWo cells following palmitic acid (PA, 500 uM) and/or TNF-alpha (10 ng/ml) treatment for 24 h. Microarray analysis revealed that placental cytotrophoblasts increased expression of genes related to inflammation, stress response and immediate-early factors in response to plamitic acid, TNF-alpha or a combination of both. Our results suggest that fatty acids and inflammatory cytokines induce inflammation in placental cells via activation of JNK-Egr-1 signaling. global transcriptomic profiling in BeWo cells following palmitic acid (PA, 500 uM) and/or TNF-alpha (10 ng/ml) treatment for 24 h
Experiment type
transcription profiling by array 
Contacts
Kartik Shankar <shankarkartik@uams.edu>, Aline Andres, Horacio Gomez-Acevedo, Jessica Saben, Keshari M Thakali, Sarah J Borengasser, Ying Zhong
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-43685.idf.txt
Sample and data relationshipE-GEOD-43685.sdrf.txt
Raw data (1)E-GEOD-43685.raw.1.zip
Processed data (1)E-GEOD-43685.processed.1.zip
Array designA-AFFY-44.adf.txt
Links