E-GEOD-42977 - Sequential Binary Gene-Ratio Tests Define a Novel Molecular Diagnostic Strategy for Malignant Pleural Mesothelioma
Released on 1 May 2013, last updated on 2 June 2014
The gene-expression ratio technique was used to design a molecular signature to diagnose MPM from among other potentially confounding diagnoses and differentiate the epithelioid from the sarcomatoid histological subtype of MPM. Microarray analysis was performed on 113 specimens including MPMs and a spectrum of tumors and benign tissues comprising the differential diagnosis of MPM. A sequential combination of binary gene-expression ratio tests was developed to discriminate MPM from other thoracic malignancies . This method was compared to other bioinformatic tools and this signature was validated in an independent set of 170 samples. Functional enrichment analysis was performed to identify differentially expressed probes.
transcription profiling by array
Assunta De Rienzo, Beow Y Yeap, John Quackenbush, Lucian R Chirieac, Melissa H Coleman, Peter E Sugarbake, Raphael Bueno, Roderick V Jensen, William G Richards, Yaoyu E Wang