E-GEOD-42941 - Vertebrate GAGA factor associated insulator elements demarcate homeotic genes in the HOX clusters

Status
Released on 1 May 2013, last updated on 2 June 2014
Organism
Mus musculus
Samples (6)
Array (1)
Protocols (5)
Description
Hox genes impart segment identity to body structures along the anterior-posterior axis and are crucial for the proper development of all organisms. Multiple regulatory elements, best defined in Drosophila melanogaster, ensure that Hox expression patterns follow the spatial and temporal colinearity reflected in their tight genomic organization. However, the precise mechanisms that regulate colinear patterns of Hox gene expression remain unclear, especially in higher vertebrates where it is not fully determined how the distinct activation domains of the tightly clustered Hox genes are defined independent of each other. Here, we report the identification of a large number of novel cis-elements at mammalian Hox clusters that can help in regulating their precise expression pattern. Agilent two-color ChIP-on-Chip experiment, Organism: Mus musculus ,Genotypic Technology designed Custom Mouse 1 million ChIP-on-chip Array (AMADID-0245671)
Experiment type
ChIP-chip by tiling array 
Contacts
Genotypic technology <genomics@genotypic.co.in>, Deepika Puri, Hita S Garapati, Jyotsna Dhawan, Rakesh K Mishra, Surabhi Srivastava
MIAME
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