array scanning protocol
Arrays were imaged using BeadArray Reader using standard recommended Illumina scanner setting.
normalization data transformation protocol
Illumina GenomeStudio software Unmethylated(Signal_A) and methylated(Signal_B) signal intensities ID_REF = VALUE = Average Beta Detection Pval =
bisulfite converted DNA was amplified, fragmented and hybridized to Illumina Infinium Human Methylation27 Beadchip using standard Illumina protocol.
Standard Illumina protocol
nucleic acid extraction protocol
Genomic DNA extraction and purification from cultured cells was carried out using a Gentra Puregene kit (QIAGEN).