E-GEOD-42351 - Genome-wide gene expression profiling of high-grade osteosarcoma cell lines

Released on 6 June 2013, last updated on 2 June 2014
Homo sapiens
Samples (19)
Array (1)
Protocols (5)
We performed genome-wide gene expression data of high-grade osteosarcoma cell lines, as well as on mesenchymal stem cells, and osteoblasts, and performed global test analysis in order to determine the most significantly affected KEGG pathways. Genome-wide gene expression analysis was performed on 19 high-grade osteosarcoma cell lines. Significantly differentially expressed genes were determined between osteosarcoma cells and two different sets of control samples - osteoblasts [n=3, GEO accession number GSE33382] and mesenchymal stem cells [n=12, GEO accession number GSE28974]. Global test was applied to the different analyses, in order to determine the most affected signaling pathways in osteosarcoma cells.
Experiment type
transcription profiling by array 
Marieke Lydia Kuijjer <geo@ncbi.nlm.nih.gov>, Anne-Marie Cleton-Jansen, Bass Hassan, Brendy E van den Akker, Elisabeth F Peterse, Inge H Briaire-deBruijn, Leonardo A Meza-Zepeda, Marieke L Kuijjer, Massimo Serra, Ola Myklebost, Pancras C Hogendoorn
IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma. Kuijjer ML, Peterse EF, van den Akker BE, Briaire-de Bruijn IH, Serra M, Meza-Zepeda LA, Myklebost O, Hassan AB, Hogendoorn PC, Cleton-Jansen AM. , Europe PMC 23688189