E-GEOD-42187 - Gene expression profile in melanomas from Pdk1-inactivated BrafV600E::Pten-/- mice
Released on 17 September 2013, last updated on 2 June 2014
Gene expression profiling was performed to access the changes in gene expression in melanomas from Pdk1-inactivated Brafv600E::Pten-/- mice. The expression profiles of the BrafV600E::Pten-/-::Pdk1-/- were compared to the BrafV600E::Pten-/-::Pdk+/+ genotypes. The analysis has identified several important signaling pathways in Pdk1-dependent melanomagenesis. Melanoma tumors from the BrafV600E::Pten-/-::Pdk1+/+ and BrafV600E::Pten-/-::Pdk1-/- genotypes were harvested and mRNA from each group was pooled to enable four biologically replicates analysis.
transcription profiling by array
Jian-Liang Li <firstname.lastname@example.org>, Jian L Li, Marzia Scortegagna, Ze’ev A Ronai
Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf<sup>V600E</sup>::Pten<sup>-/-</sup> melanoma. Scortegagna M, Ruller C, Feng Y, Lazova R, Kluger H, Li JL, De SK, Rickert R, Pellecchia M, Bosenberg M, Ronai ZA. , Europe PMC 24037523