E-GEOD-41418 - Pancreatic gene expression associated with cerulein induced chronic pancreatitis in mice

Released on 10 October 2012, last updated on 1 October 2015
Mus musculus
Samples (12)
Array (1)
Protocols (6)
A frequently used experimental model of chronic pancreatitis (PC) recapitulating human disease is repeated injection of cerulein to mice. We found that two common substrains of C57BL/6 , C56BL/6J (Jackson) and C57BL/6NHsd (Harlan), exhibit different degree of CP with C57BL/6J beeing more susceptible to repetitive cerulein induced CP. The goal of this study was to identify genes associated with CP and also to identify genes differentially regulated between two substrains as candidates for the CP progression. RNAs were isolated from the pancreas of 8-week old Jackson and Harlan mice after the cerulein induction of chronic pancreatitis and hybridized on Affymetrix microarrays. Saline injected mice were used as controls. Three mice from each experimental and control groups were used in the experiment.
Experiment type
transcription profiling by array 
Ulmasov B, Oshima K, Rodriguez MG, Cox RD, Neuschwander-Tetri BA. Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis. , Europe PMC 23845568
Investigation descriptionE-GEOD-41418.idf.txt
Sample and data relationshipE-GEOD-41418.sdrf.txt
Raw data (1)E-GEOD-41418.raw.1.zip
Processed data (1)E-GEOD-41418.processed.1.zip
Array designA-AFFY-45.adf.txt