E-GEOD-41400 - Lipid metabolism genes in contralateral unaffected breast and estrogen receptor status of breast cancer

Released on 26 March 2013, last updated on 2 June 2014
Homo sapiens
Samples (30)
Array (1)
Protocols (10)
The contralateral unaffected breast of women with unilateral breast cancer (cases) is a good model for defining subtype-specific risk since women with ER-negative index primaries are at high risk for subsequent ER-negative primary cancers. We performed random fine needle aspiration (rFNA) of the unaffected breasts of cases; samples from 30 subjects (15 ER-positive and 15 ER-negative cases matched for age, race and menopausal status), were used for Illumina expression array analysis. In this study, we have examined gene expression profiles in random fine needle aspirate (rFNA) samples from the contralateral breasts of women with new unilateral breast cancer (cases) to seek candidate panels of ER-specific risk biomarkers. On a discovery set of 30 women, we have identified gene expression differences in the contralateral breast that associate with ER+ or ER- index primary tumors.
Experiment type
transcription profiling by array 
Jun Wang <j-wang4@northwestern.edu>, Denise Scholtens, Seema A Khan
Investigation descriptionE-GEOD-41400.idf.txt
Sample and data relationshipE-GEOD-41400.sdrf.txt
Raw data (1)E-GEOD-41400.raw.1.zip
Processed data (1)E-GEOD-41400.processed.1.zip
Array designA-MEXP-1173.adf.txt