E-GEOD-40955 - Allele-specific Methylation of Human Placental Tissue

Released on 9 October 2013, last updated on 3 May 2014
Homo sapiens
Samples (10)
Protocols (4)
In this study, we screened human placental samples for allele-specific methylation and subsequently novel imprinted genes associated with these regions. We used reduced representation bisulfite sequencing to identify partially methylated CpG islands (CGIs) in the human placental genome. We were able to delineate potential candidates for allele-specific methylation based on the calculation of a concordance statistic. Amongst the 28 regions chosen for validation based on high levels of expression, two regions were shown to exhibit allele-specific expression. Single base-resolution methylation analysis in the placental genome and RNA-Seq
Experiment types
methylation profiling by high throughput sequencing, RNA-seq of coding RNA 
DNMT1 and AIM1 Imprinting in human placenta revealed through a genome-wide screen for allele-specific DNA methylation. Das R, Lee YK, Strogantsev R, Jin S, Lim YC, Ng PY, Lin XM, Chng K, Yeo GSh, Ferguson-Smith AC, Ding C. , Europe PMC 24094292
Exp. designProtocolsVariablesProcessedSeq. reads
Investigation descriptionE-GEOD-40955.idf.txt
Sample and data relationshipE-GEOD-40955.sdrf.txt
Additional data (1)E-GEOD-40955.additional.1.zip