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E-GEOD-40881 - The effect on gene expression of Smchd1 deletion in premalignant pre-B cells

Status
Released on 30 September 2012, last updated on 18 October 2012
Organism
Mus musculus
Samples (12)
Array (1)
Protocols (19)
Description
Smchd1 appears to act as a tumour suppressor in the Eµ-Myc B cell lymphoma model. We find gene expression differences are most pronounced in premalignant cells. We always detect a small number of clustered genes and imprinted genes as differentially expressed, along with others involved in tumorigenesis. The microarrays compared Smchd1 null and Smchd1 wildtype samples from premalignant pre-B cells. All samples are on the C57BL/6 background, and carry the Eµ-Myc transgene. Smchd1 null samples are additionally homozygous for a Smchd1 genetrap allele.
Experiment type
transcription profiling by array 
Contacts
Gordon K Smyth, Huei S Leong, Marnie E Blewitt, Yifang Hu
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-40881.idf.txt
Sample and data relationshipE-GEOD-40881.sdrf.txt
Processed data (1)E-GEOD-40881.processed.1.zip
Additional data (1)E-GEOD-40881.additional.1.zip
Array designA-MEXP-1175.adf.txt
Links