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E-GEOD-40418 - p53 prevents neurodegeneration by regulating synaptic genes

Released on 6 January 2015, last updated on 10 January 2015
Drosophila melanogaster
Samples (8)
Array (1)
Protocols (5)
DNA damage has been implicated in neurodegenerative disorders, including Alzheimer’s disease and other tauopathies, but the consequences of genotoxic stress to postmitotic neurons are poorly understood. Here we demonstrate that p53, a key mediator of the DNA damage response, plays a neuroprotective role in a Drosophila model of tauopathy. Further, through a whole-genome ChIP-chip analysis we identify genes controlled by p53 in postmitotic neurons. We genetically validate a specific pathway, synaptic function, in p53-mediated neuroprotection. We then demonstrate that the control of synaptic genes by p53 is conserved in mammals. Collectively, our results implicate synaptic function as a central target in p53-dependent protection from neurodegeneration. 4 samples: tau vs. control
Experiment type
ChIP-chip by tiling array 
Mel B Feany, Paola Merlo, Peter J Park, Shouyong Peng, Yawei J Yang
p53 prevents neurodegeneration by regulating synaptic genes. Merlo P, Frost B, Peng S, Yang YJ, Park PJ, Feany M. , PMID:25453105