E-GEOD-40413 - IL-17 and TNF synergistically induce growth-associated cytokines in melanocytes while suppressing melanogenesis

Status
Released on 15 June 2013, last updated on 2 June 2014
Organism
Homo sapiens
Samples (12)
Array (1)
Protocols (7)
Description
In this study, we sought to determine how IL-17 and TNF influence normal human melanocytes, either alone, or with both cytokines together. We reveal a dichotomous effect of IL-17 and TNF, which not only elicit essential mitogenic cytokines but also suppress melanogenesis by down-regulating genes of melanogenesis pathway Comparison of one batch of primary human melanocyte line cultured in serum free media, treated with TNF and/or IL-17, for either 24 or 48 hours.
Experiment type
transcription profiling by array 
Contacts
Claire Q.F. Wang <qwang@rockefeller.edu>, Claire Q Wang, James G Krueger, Mayte Suárez-Fariñas
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-40413.idf.txt
Sample and data relationshipE-GEOD-40413.sdrf.txt
Raw data (1)E-GEOD-40413.raw.1.zip
Processed data (1)E-GEOD-40413.processed.1.zip
Array designA-AFFY-44.adf.txt
Links