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E-GEOD-40085 - Expression data from Amacr knock-out mouse liver

Released on 22 December 2015, last updated on 26 December 2015
Mus musculus
Samples (8)
Array (1)
Protocols (5)
Bile acids play multiple roles in vertebrate metabolism by facilitating lipid absorption in the intestine and acting as a signaling molecule in lipid and carbohydrate metabolism. Bile acids are also the main route to excrete excess cholesterol out of the body. Alpha-methyl-Coa racemase (Amacr) is one of the enzymes needed to produce bile acids from cholesterol. The mouse model lacking Amacr can produce only minor (less than 10%) amounts of bile acids, but still they are symptomless in normal laboratory conditions. Bile acid synthesis occurs in liver. In this experiment, liver samples from Amacr-/- and wild-type mice were collected and their gene expression levels were compared. 4 biological replicates per genotype.
Experiment type
transcription profiling by array 
Phytol is lethal for Amacr-deficient mice. Selk�l� EM, Nair RR, Schmitz W, Kvist AP, Baes M, Hiltunen JK, Autio KJ. , PMID:26248199
Investigation descriptionE-GEOD-40085.idf.txt
Sample and data relationshipE-GEOD-40085.sdrf.txt
Raw data (1)
Processed data (1)
Array designA-GEOD-14661.adf.txt