Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.
E-GEOD-40066 - Genetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility
Released on 1 November 2012, last updated on 8 November 2012
This study investigates three radiation exposure scenarios in BALB/c and C57BL/6 mice: (1) low dose (LD) group -- four weekly doses of 7.5 cGy, (2) high dose (HD) group -- four weekly doses of 1.8 Gy, (3) unexposed group -- four weekly sham exposures. We then used comparative expression profiles of the mouse mammary gland and cardiac blood to build a model of candidate tissue functions associated with LD cancer susceptibility in these strains and murine and human knowledgebases to characterize these tissue functions and their relevance to breast cancer. All samples were assessed on Affymetrix MOE 430 A arrays (HT_MG-430A; GPL8759). Mammary gland tissues: 43 samples (2 strains, 3 treatments, 2 timepoints, 2-4 replicates). For Cardiac blood tissue: 8 samples (2 strains, 4 replicates)
transcription profiling by array
Antoine M Snijders <AMSnijders@lbl.gov>, Andrew J Wyrobek, Francesco Marchetti, Jian-Hua Mao, Joe Gray, Ju Han, Nadire Duru, Sandhya Bhatnagar, Zhi Hu
Genetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility. Snijders AM, Marchetti F, Bhatnagar S, Duru N, Han J, Hu Z, Mao JH, Gray JW, Wyrobek AJ. , PMID:23077491