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E-GEOD-40066 - Genetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility

Status
Released on 1 November 2012, last updated on 8 November 2012
Organism
Mus musculus
Samples (51)
Array (1)
Protocols (8)
Description
This study investigates three radiation exposure scenarios in BALB/c and C57BL/6 mice: (1) low dose (LD) group -- four weekly doses of 7.5 cGy, (2) high dose (HD) group -- four weekly doses of 1.8 Gy, (3) unexposed group -- four weekly sham exposures. We then used comparative expression profiles of the mouse mammary gland and cardiac blood to build a model of candidate tissue functions associated with LD cancer susceptibility in these strains and murine and human knowledgebases to characterize these tissue functions and their relevance to breast cancer. All samples were assessed on Affymetrix MOE 430 A arrays (HT_MG-430A; GPL8759). Mammary gland tissues: 43 samples (2 strains, 3 treatments, 2 timepoints, 2-4 replicates). For Cardiac blood tissue: 8 samples (2 strains, 4 replicates)
Experiment type
transcription profiling by array 
Contacts
Antoine M Snijders <AMSnijders@lbl.gov>, Andrew J Wyrobek, Francesco Marchetti, Jian-Hua Mao, Joe Gray, Ju Han, Nadire Duru, Sandhya Bhatnagar, Zhi Hu
Citation
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-40066.idf.txt
Sample and data relationshipE-GEOD-40066.sdrf.txt
Raw data (1)E-GEOD-40066.raw.1.zip
Processed data (1)E-GEOD-40066.processed.1.zip
Array designA-GEOD-8759.adf.txt
Links