Please note that we have stopped the regular imports of Gene Expression Omnibus (GEO) data into ArrayExpress. This may not be the latest version of this experiment.

E-GEOD-39850 - 5 Day Oral Study of A-998679 in Male Sprague Dawley Rats (Jejunum)

Status
Released on 3 August 2012, last updated on 13 August 2012
Organism
Rattus norvegicus
Samples (10)
Array (1)
Protocols (7)
Description
Male Sprague-Dawley rats [Crl:CD®(SD)IGS BR], weighing ~250 g at study initiation were obtained from Charles River Laboratories, Inc. (Wilmington, MA). Rats were housed singly in ventilated, stainless steel, wire-bottom hanging cages and fed non-certified Rodent Chow (Harlan Labs, Madison, WI) and water ad libitum and acclimated for at least 5 days after arrival. Rats were randomly assigned to various treatment groups (3 rats/group) and were dosed once daily by oral gavage with vehicle (0.2% hydroxypropylmethylcellulose at a dose volume of 10 ml/kg) or with 30, 100, or 200 mg/kg of A-998679. All rats were fasted overnight after their last dose, weighed and sacrificed under isoflurane anesthesia. Liver and small intestine (jejunum) were flash frozen in liquid nitrogen and stored at −80°C until processing for gene expression profiling on the Affymetrix platform. total of 11 samples, 3 biological replicates (rats) from each of 3 treatments groups 1. vehicle control 2. 30mg/kg A-998679 3. 100mg/kg A-998679 and 2 biological replicates from treatment group 4. 200mg/kg A-998679
Experiment type
transcription profiling by array 
Contacts
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-39850.idf.txt
Sample and data relationshipE-GEOD-39850.sdrf.txt
Raw data (1)E-GEOD-39850.raw.1.zip
Processed data (1)E-GEOD-39850.processed.1.zip
Additional data (1)E-GEOD-39850.additional.1.zip
Array designA-AFFY-43.adf.txt
R ExpressionSetE-GEOD-39850.eSet.r
Links