E-GEOD-3790 - Transcruption profiling of human cerebellum, frontal cortex [BA4, BA9] and caudate nucleus HD tissue experiment

Released on 12 September 2009, last updated on 27 March 2012
Homo sapiens
Samples (404)
Arrays (2)
Protocols (4)
Post mortem human brain tissue comparison between HD patients and controls from 3 brain regions - cerebellum, frontal cortex [BA4, BA9] and caudate nucleus. Gene expression analysed using linear models from LIMMA package in Bioconductor suite. Experiment Overall Design: Large sample sizes were used to examine brain tissue gene expression at various stages of HD pathology. Three brain regions were profiled, compared and analysed for differential gene expression. The broad aim was to capture early stage gene expression changes in HD brains.
Experiment types
transcription profiling by array, unknown experiment type
Regional and cellular gene expression changes in human Huntington's disease brain. Angela Hodges, Andrew D. Strand, Aaron K. Aragaki, Alexandre Kuhn, Thierry Sengstag, Gareth Hughes, Lyn A. Elliston, Cathy Hartog, Darlene R. Goldstein, Doris Thu, Zane R. Hollingsworth, Francois Collin, Beth Synek, Peter A. Holmans, Anne B. Young, Nancy S. Wexler, Mauro Delorenzi, Charles Kooperberg, Sarah J. Augood, Richard L.M. Faull, James M. Olson, Lesley Jones, and Ruth Luthi-Carter.