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E-GEOD-37843 - Expression data generated by syndecan-1 silencing in malignant mesothelioma STAV-AB cell line

Status
Released on 1 November 2012, last updated on 8 November 2012
Organism
Homo sapiens
Samples (6)
Array (1)
Protocols (8)
Description
The transcriptomic responses of syndecan-1 silencing in a human mesothelioma cell line was followed with microarray analysis. To project the transcriptome analysis on the full-dimensional picture of cellular regulation, we applied a novel method of network enrichment analysis which elucidated signalling relations between differentially expressed genes and pathways acting via various molecular mechanisms. Our results suggest that syndecan-1 regulates cell proliferation in a highly complex way, although the exact contribution of the altered pathways necessitates further functional studies. Gene expression profiles (Human Gene 1.0 ST) of malignant mesothelioma cells were studied in cells silenced for syndecan-1 (N=3) and scrambled control cells (N=3)
Experiment type
transcription profiling by array 
Contacts
Tünde Szatmári <tunde.szatmari@ki.se>, D Brodin, F Mundt, K Dobra, T Szatmári
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-GEOD-37843.idf.txt
Sample and data relationshipE-GEOD-37843.sdrf.txt
Raw data (1)E-GEOD-37843.raw.1.zip
Processed data (1)E-GEOD-37843.processed.1.zip
Array designA-AFFY-141.adf.txt
Links